Amphiphysin Autoimmunity: Associated Neurological Syndromes and Tumors in The Turkish Population

作者：Tuzun Erdem^*; Bebek Nerses; Icoz Sema; Durmus Hacer; Kurtuncu Murat; Gurses Candan; Akman Demir Guelsen

来源：Journal of Neurological Sciences-Turkish, 2010, 27(2): 121-126.

• Amphiphysin
• paraneoplastic
• cancer
• antibody

Objective: Our aim was to determine the clinical accompaniments of the amphiphysin autoimmunity in the Turkish population.
Patients and Methods: Sera of 6 patients with a subacute neurological presentation were selected because of their immunoreactivity pattern suggestive of amphiphysin-antibodies. Amphiphysin-antibody positivity was confirmed by immunoblots containing recombinant amphiphysin protein.
Results: Two patients had limbic encephalitis, 1 myelopathy and 3 neuropathy. Breast, lung and endometrium cancers were detected in one patient each. Two patients had metastasis ( of a bladder cancer and an unknown tumor) and no tumors could be found in one patient. Most or all patients exhibited normal imaging and cerebrospinal fluid (CSF) findings and poor response to immunosuppression. None of the patients' sera contained antibodies to other intracellular paraneoplastic antigens.
Conclusions: Our cohort differs from the previously reported ones by reduced frequency of abnormal CSF findings, absence of other coexisting paraneoplastic antibodies and presence of tumor types that have not been previously associated with amphiphysin autoimmunity.

• 出版日期2010