Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading I-123-Iodoamphetamine Single-Photon Emission Computed Tomography

作者：Haga Sei^*; Morioka Takato; Shimogawa Takafumi; Akiyama Tomoaki; Murao Kei; Kanazawa Yuka; Sayama Tetsuro; Arakawa Shuji

来源：Journal of Stroke and Cerebrovascular Diseases, 2016, 25(1): 1-6.

DOI：10.1016/j.jstrokecerebrovasdis.2015.08.025

• Arterial spin labeling
• postlabeling delay
• IMP SPECT
• MR perfusion image
• cerebrovascular reserve

Background: Perfusion magnetic resonance image with arterial spin labeling (ASL) provides a completely noninvasive measurement of cerebral blood flow (CBF). However, arterial transient times can have a marked effect on the ASL signal. For example, a single postlabeling delay (PLD) of 1.5 seconds underestimates the slowly streaming collateral pathways that maintain the cerebrovascular reserve (CVR). To overcome this limitation, we developed a dual PLD method. Subjects and methods: A dual PLD method of 1.5 and 2.5 seconds was compared with I-123-iodoamphetamine single-photon emission computed tomography with acetazolamide loading to assess CVR in 10 patients with steno-occlusive cerebrovascular disease. Results: In 5 cases (Group A), dual PLD-ASL demonstrated low CBF with 1.5-second PLD in the target area, whereas CBF was improved with 2.5-second PLD. In the other 5 cases (Group B), dual PLD-ASL depicted low CBF with 1.5-second PLD, and no improvement in CBF with 2.5-second PLD in the target area was observed. On single-photon emission computed tomography, CVR was maintained in Group A but decreased in Group B. Conclusions: Although dual PLD methods may not be a completely alternative test for I-123-iodoamphetamine single-photon emission computed tomography with acetazolamide loading, it is a feasible, simple, noninvasive, and repeatable technique for assessing CVR, even when employed in a routine clinical setting.

• 出版日期2016-1