Association of Hyperuricemia With Conventional Cardiovascular Risk Factors in Elderly Patients

作者：Marotta Teodoro^*; Liccardo Maria; Schettini Federico; Verde Francesco; Ferrara Aldo L

来源：Journal of Clinical Hypertension, 2015, 17(1): 27-32.

DOI：10.1111/jch.12434

The relationship between serum uric acid (UA) and cardiovascular risk profile was investigated in 557 outpatients (415 women) aged 60years and older. Patients were grouped according to a UA cutoff level of 5.5mg/dL. Prevalence of obesity, hypertension, and impaired glucose metabolism was increased in women with higher UA, who had higher body mass index (37.7 +/- 6.9 vs 33.1 +/- 5.9kg/m(2), P<.001), waist circumference, and serum glucose and triglyceride concentrations than women with lower UA levels. Conversely, men with higher UA levels showed lower high-density lipoprotein cholesterol and higher left ventricular mass than men with lower UA levels. Estimated glomerular filtration rate was reduced in patients with high UA levels of both sexes (65 +/- 17 vs 72 +/- 16mL/min/1.73m(2), P<.001, for women; 70 +/- 16 vs 76 +/- 15mL/min/1.73m(2), P<.03, for men). Grouping patients by sex-specific median UA concentrations produced similar results. These data indicate that, even in the elderly, UA clusters in a sex-specific fashion with features of metabolic syndrome and signs of target organ damage.

• 出版日期2015-1