Association of Acute Cerebellar Ataxia and Human Papilloma Virus Vaccination: A Case Report

作者：Yonee Chihiro; Toyoshima Mitsuo^*; Maegaki Yoshihiro; Kodama Yuichi; Hayami Hiroshi; Takahashi Yukitoshi; Kusunoki Susumu; Uchibori Ayumi; Chiba Atsuro; Kawano Yoshifumi

来源：Neuropediatrics, 2013, 44(5): 265-267.

DOI：10.1055/s-0033-1333873

• acute cerebellar ataxia
• human papilloma virus vaccination
• immunoadsorption plasmapheresis therapy

Introduction We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine. Patient and Method This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis. Results Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis. Conclusion This temporal association strongly suggests that ACA was induced by the vaccination.

• 出版日期2013-10