Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

作者：Lazcano Perez Fernando^*; Castro Hector; Arenas Isabel; Garcia David E; Gonzalez Munoz Ricardo; Arreguin Espinosa Roberto^*

来源：Toxins, 2016, 8(5): 135.

DOI：10.3390/toxins8050135

• cnidaria
• zoanthids
• Palythoa caribaeorum
• voltage-gated ion channels
• SCG neurons
• MALDI-TOF-MS

The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P. caribaeorum venom on voltage-gated sodium channel (Na(V)1.7), voltage-gated calcium channel (Ca(V)2.2), the A-type transient outward (I-A) and delayed rectifier (I-DR) currents of K-V channels of the superior cervical ganglion (SCG) neurons of the rat. These results showed that the venom reversibly delays the inactivation process of voltage-gated sodium channels and inhibits voltage-gated calcium and potassium channels in this mammalian model. The compounds responsible for these effects seem to be low molecular weight peptides. Together, these results provide evidence for the potential use of zoanthids as a novel source of cnidarian toxins active on voltage-gated ion channels.

• 出版日期2016-5