A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives

作者：Khaleghi Fatemeh; Bin Din Laily; Jantan Ibrahim; Yaacob Wan Ahmad; Khalilzadeh Mohammad A^*

来源：Tetrahedron Letters, 2011, 52(52): 7182-7184.

DOI：10.1016/j.tetlet.2011.10.129

An efficient and simple synthesis of 1,4-benzoxazepin-2-one derivatives has been achieved via the reaction of isoquinoline, activated acetylenes, and 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone in water without using any catalyst. This one-pot reaction occurs in high yields under mild conditions.

• 出版日期2011-12-28