The Study of the Concentration Increasing Effect in the Combination of Zinc Ion with Human Growth Hormone by Molecular Dynamics Simulation

作者：Tayyebi S; Tazikeh Lemeski E^*

来源：Iranian Journal of Science and Technology Transaction A-Science, 2017, 41(A2): 329-335.

DOI：10.1007/s40995-016-0026-7

• Human Growth Hormone
• Molecular dynamics simulation
• Hydrogen bond
• Secondary structure

In this study, we examined the stability of human growth hormone (hGH) in the presence of two different concentrations of zinc ions at the molecular level using molecular dynamics simulation for 30 ns. Analysis of the obtained trajectory of the molecular dynamics simulation (root mean square deviation, root mean square fluctuation, DSSP, hydrogen bond, radius of gyration, solvent accessible surface area and dynamic cross-correlation map) shows that the hGH protein structure is stabilized in the presence of Zn2+ ions, especially in 0.025 M of zinc ions. Our findings are in good agreement with our previous experimental study.

• 出版日期2017-6