Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes

作者：Freixenet Nuria^*; Vilardell Carme; Llaurado Gemma; Gimenez Palop Olga; Berlanga Eugenio; Gutierrez Cristina; Caixas Assumpta; Vendrell Joan; Miguel Gonzalez Clemente Jose

来源：Diabetes Research and Clinical Practice, 2011, 91(2): E33-E36.

DOI：10.1016/j.diabres.2010.10.003

• Iron overload
• Type 2 diabetes
• Insulin secretion
• Insulin sensitivity
• Metabolic syndrome

Aim: To assess the role of iron overload in type 2 diabetic men with hyperferritinemia.
Methods: 150 men were recruited from a genetic screening programme for hereditary hemocromatosis (HH) and were tested for type 2 diabetes, other components of the metabolic syndrome, beta cell BCF), insulin sensitivity, high-sensitivity C-reactive protein and iron overload.
Results: Fifty-one men had type 2 diabetes. They were older (p = 0.017) and 99 had lower BCF (p < 0.001) than non-diabetic men. None of the iron overload indexes was associated with diabetes.
Conclusions: Our findings dispute a role of iron overload in the pathogenesis of type 2 diabetes.

• 出版日期2011-2