Adipocyte-brain crosstalk. Relevance for the pathogenesis of the metabolic syndrome

作者：Machleidt F^*; Ott V; Lehnert H

来源：Diabetologe, 2013, 9(6): 449-454.

DOI：10.1007/s11428-013-1061-z

• Obesity
• Adipokines
• Leptin
• Energy homeostasis
• Central nervous system

Beyond the mere storage of lipids adipose tissue plays a crucial role in the regulation of whole body energy balance. To communicate with other organs, e.g. the central nervous system and the liver, adipose tissue secretes a range of adipokines, i.e. adipocyte-derived hormones. Adipokines, such as leptin, not only inform other organs about the current availability of energy in the form of fat but also exert numerous effects on the metabolic, neuronal and cognitive-emotional level. In states of a pathological increase of fat mass a change in the adipokine profile can be observed. These changes in the body periphery and central nervous system seem to be causally involved in the development of the metabolic syndrome. Adipokine-based interventions, although not yet established, open up intriguing possibilities for the treatment of the metabolic syndrome.

• 出版日期2013-9