Detection of Ro/SS-A antibodies in lupus erythematosus: What does it mean for the dermatologist?

作者：Boeckle Barbara C; Stanarevic Gunda; Sepp Norbert T

来源：Journal of the American Academy of Dermatology, 2013, 68(3): 385-394.

DOI：10.1016/j.jaad.2012.09.024

• internal organ involvement
• lupus erythematosus
• lupus erythematosus-nonspecific cutaneous manifestations
• lupus erythematosus-specific cutaneous manifestations
• Ro/SS-A antibody

Background: Lupus erythematosus (LE) is a systemic autoimmune disease. However, some patients have only cutaneous LE (CLE), whereas others develop internal organ involvement. Ro/SS-A antibodies are frequently detected in photosensitive variants of LE. %26lt;br%26gt;Objective: The prevalence of LE-specific and LE-nonspecific cutaneous manifestations and their relation to internal organ involvement in Ro/SS-A antibody-positive patients were investigated. %26lt;br%26gt;Methods: All Ro/SS-A-positive patients between January 2000 and December 2011 were reviewed. Only patients with Ro/SS-A antibodies and LE were enrolled and retrospectively analyzed. %26lt;br%26gt;Results: In all, 215 Ro/SS-A antibody-positive patients were given the diagnosis of LE. Older patients (%26gt;50 years old) presenting with subacute CLE or chronic CLE and negative antinuclear antibody usually only experienced skin involvement. In contrast, internal organ involvement was observed in younger patients (%26lt;50 years old) with subacute CLE or chronic CLE presenting with the clinical and laboratory markers: fatigue, positive antinuclear antibody, and additional extractable nuclear antigen. Young female patients with acute CLE should be recognized as a separate subset of Ro/SS-A antibody-positive patients because almost a third was given the diagnosis of kidney involvement. Logistic regression analysis revealed that internal organ involvement was observed in patients with LE presenting with LE-nonspecific cutaneous manifestations, arthralgia, leukopenia, positive antinuclear antibody, and fatigue. %26lt;br%26gt;Limitations: This was a retrospective study from a single referral center specializing in dermatologic diseases. %26lt;br%26gt;Conclusion: The particular cutaneous variant of LE and age at Ro/SS-A detection predict different risks for internal organ involvement in Ro/SS-A antibody-positive patients with LE. (J Am Acad Dermatol 2013;68:385-94.)

• 出版日期2013-3