An efficient green MCR protocol for the synthesis of 2,4,5-trisubstituted imidazoles by Selectfluor (TM) under ultrasound irradiation

作者：Heravi Mohammad Reza Poor^*; Vessally Esmaeil; Behbehani Gholam R Rezaei

来源：Comptes Rendus Chimie, 2014, 17(2): 146-150.

DOI：10.1016/j.crci.2012.12.007

• Ultrsound irradiation
• One-pot synthesis
• Triarylmidazoles
• Benzil
• MCRs
• Benzil
• Selectfluor (TM)

A simple, efficient and eco-friendly procedure has been developed using Selectfluor (TM) (15% mol) as a novel catalyst under ultrasound irradiation and solvent-free conditions for the synthesis of 2,4,5-triaryimidazole by a three-component, one-pot condensation of benzil, aryl aldehydes and ammonium acetate. The present methodology offers several advantages such as excellent yields, shorter reaction times (10-15 min) and environmentally benign milder reaction conditions and easy work-up.

• 出版日期2014-2