Development of murine models to study Hepatitis C virus induced liver pathogenesis

作者：Khalid Madiha; Manzoor Sobia^*; Imran Muhammad; Tariq Muqddas; Ashraf Javed; Ahmed Qazi Laeeque; Ashraf Waseem; Parvaiz Fahed; Ashraf Muhammad

来源：Indian Journal of Virology, 2013, 24(2): 151-156.

DOI：10.1007/s13337-013-0152-1

• Murine models
• Hepatitis C virus
• Liver pathogenisis

Hepatitis C virus (HCV) is involved in different liver pathologies worldwide. In contemporary scenario, HCV treatment is lagging behind owing to absence of vaccines against virus. The only consideration for HCV treatment is pegylated interferon-alpha and ribavirin that results in sustained virological response in 50 % of patients. Two feasible hosts for HCV infection are chimpanzee and humans. For decades, chimpanzees are sole host to study HCV pathogenesis, but their use is limited due to ethical issues. The dilemma behind HCV therapy is the need of sustainable animal models that can help simulate in vivo conditions. We have assembled recent advances in animal models to study liver diseases for targeted therapy.

• 出版日期2013-9