A Facile Copper-Catalyzed One-Pot Domino Synthesis of 5,12-Dihydroindolo[2,1-b]quinazolines

作者：Jiang, Min; Li, Jian; Wang, Feng; Zhao, Yichao; Zhao, Feng; Dong, Xiaochun^*; Zhao, Weili

来源：Organic Letters, 2012, 14(6): 1420-1423.

DOI：10.1021/ol3001624

• C-N
• COUPLING REACTIONS
• EFFICIENT APPROACH
• CASCADE SYNTHESIS
• TANDEM SYNTHESIS
• ARYL IODIDES
• ACID
• LIGAND
• VERSATILE
• ANALOGS

A domino synthesis of 5,12-dihydroindolo[2,1-b]quinazoline derivatives via copper-catalyzed Ullmann-type intermolecular C-C and intramolecular C-N couplings is reported. Good yields of various 5,12-dihydroindolo[2,1-b]quinazoline derivatives were obtained. Reaction scopes, limitations, and the reaction mechanism are discussed.

• 出版日期2012-3-16
• 单位复旦大学; 河南大学