Multi-centre assessment of mycotic rhinosinusitis in dogs: a retrospective study of initial treatment success (1998 to 2008)

作者：Sharman M^*; Paul A; Davies D; MacKay B; Swinney G; Barrs V; Arteaga A; Robertson I D; Mansfield C

来源：Journal of Small Animal Practice, 2010, 51(8): 423-427.

DOI：10.1111/j.1748-5827.2010.00957.x

Methods: Medical records of dogs treated for mycotic rhinosinusitis were obtained retrospectively via a manual review of the clinical databases of six veterinary referral centres for the period of January 1998 to June 2008, and first treatment outcome was evaluated. Historical and clinicopathological findings were also reviewed to evaluate their impact on treatment success or failure.
Results: There was no significant difference in first treatment outcome between treatment groups (P=0 center dot 21). When all topical treatments were considered together (n=85), 39 dogs (45 center dot 8%) had a successful first treatment. Initial treatment success was associated with a younger age (56 center dot 3 versus 75 center dot 8 months; P=0 center dot 02) and was 2 center dot 7 times more likely in dogs with unilateral disease, although this was not significant (P=0 center dot 07). Adjunctive therapy with systemic antifungal agents was associated with treatment failure (PA0 center dot 01). Fifty-nine dogs (69 center dot 4%) responded successfully following multiple treatments.
Clinical Significance: Treatment of mycotic rhinosinusitis remains challenging, and multiple treatments are frequently required for adequate treatment. Reasons for first treatment failure are likely multifactorial in origin, making it difficult to predict those dogs that are likely to have a superior prognosis, regardless of the treatment type used.

• 出版日期2010-8