Effect of Lawsonia inermis on tumor expression induced by Dalton's lymphoma ascites in Swiss albino mice

作者：Priya R; Ilavenil S; Kaleeswaran B; Srigopalram S; Ravikumar S^*

来源：Saudi Journal of Biological Sciences, 2011, 18(4): 353-359.

DOI：10.1016/j.sjbs.2011.04.001

• Antitumor
• Lawsonia inermis
• Pathophysiological
• Antioxidant
• Histopathological

The purpose of this study was investigating experimentally the possible antitumor effect of ethanol extract of root of Lawsonia inermis against Dalton's lymphoma ascites (DLA) bearing mice.
Mice were administered with L. inermis at a dosage of 180 mg/kg of body weight for 15 days after 24 h of DLA inoculation. The ethanolic root extract of L. inermis reverted the increased number of the WBC count, platelets and lymphocytes and decreased the number of the RBC count, hemoglobin content and monocytes. The effect of root extract of L. inermis also increased the pathophysiological marker enzyme, lipid profile and decreased the enzymic and non enzymic antioxidants. A histopathological result shows the loss of liver hepatocytes and kidney architecture in DLA bearing mice. However, mice treatment with L. inermis extract improves the liver and kidney function and rearranges more or less normal architecture. The present work indicates that the ethanol extract of L. inermis exhibited significant antitumor activity.

• 出版日期2011-10