A single intramuscular injection of Gonadorelin [6-D-Phe] induces ovulation in the mare

作者:Osmers Jan Hendrik*; Martinsson Gunilla; Klewitz Jutta; Linke Corinna; Zaremba Wolfgang; Sieme Harald
来源:Pferdeheilkunde, 2011, 27(3): 220-223.
DOI:10.21836/PEM20110303

摘要

Artificial use of hormones in stud farm practice has become a widely used tool to enhance the success of equine breeding programs. Human chorionic gonadotropin (hCG) and GnRH implants are the most commonly used ovulation inducing agents. Despite their proven effectiveness, several disadvantages have been reported. Since there is no published data on the effect of the GnRH analogue Gonadorelin [6-D-Phe] (Gonavet Veyx (R)) on ovulation in horses, it was the aim of this study to evaluate whether a single intramuscular injection is able to induce ovulation within 48 hours. A total of 82 mares received a treatment with 100 mu g of Gonadorelin [6-D-Phe] as soon as estrus and a follicle-diameter >35 mm were detected. Manual rectal palpation and ultrasound examination were performed at 12-hour-intervals after the treatment. Eighty five percent of mares ovulated within 48 hours. Of the 18 untreated control mares, 38% ovulated within 48 hours. The mean duration until ovulation in the Gonadorelin [6-D-Phe] and control group was 41 +/- 10.17 and 57 +/- 15.15 hours, respectively (p<0.05). The efficacy of Gonadorelin [6-D-Phe] in inducing ovulation within 48 hours post application increased from early breeding season in February - March (75.9 %) to mid and late season in April - July (89.9%). An influence of mare's age and/or reproductive status on the response to Gonadorelin [6-D-Phe] - treatment could not be observed. Gonadorelin [6-D-Phe) could be considered as a reliable and easy-to-use alternative to induce ovulation in the mare.

  • 出版日期2011-6

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