A Facile Synthesis of 5 %26apos;-Fluoro-5 %26apos;-deoxyacadesine (5 %26apos;-F-AICAR): A Novel Non-phosphorylable AICAR Analogue

作者：D' Errico Stefano; Oliviero Giorgia^*; Borbone Nicola; Amato Jussara; D' Alonzo Daniele; Piccialli Vincenzo; Mayol Luciano; Piccialli Gennaro

来源：Molecules, 2012, 17(11): 13036-13044.

DOI：10.3390/molecules171113036

• AICAR
• ZMP
• AMPK
• AMPK activation
• fluorinated nucleosides
• fluorination
• imidazole nucleosides
• nucleoside analogues
• modified nucleosides

The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5%26apos;-fluoro-5%26apos;-deoxyacadesine (5%26apos;-F-AICAR), a strict analogue of AICAR that cannot be 5%26apos;-phosphorylated to ZMP by cellular kinases, is reported.

• 出版日期2012-11