Acute renal failure with acyclovir treatment in a child with leukemia

作者：Genc Guerkan^*; Ozkaya Ozan; Acikgoz Yonca; Yapici Oktay; Bek Kenan; Sensoy Sema Guelnar; Ozyurek Emel

来源：Drug and Chemical Toxicology, 2010, 33(2): 217-219.

DOI：10.3109/01480540903311076

• Acyclovir
• children
• renal failure
• acute lymphoblastic leukemia

Acyclovir is an effective, frequently used antiviral agent. Adverse effects of this drug are well known and are especially seen with high doses and/or dehydration. In this article, we report a 6-year-old boy with leukemia with nonoliguric acute renal failure in normal hydration status after using acyclovir treatment. He had no preexisting renal impairment, and there were no additional symptoms. Dimercaptosuccinic acid radionucleid scyntigraphy and other laboratory findings revealed impairment of proximal tubule function, in addition to distal tubule. We emphasize that renal functions should be monitored carefully during treatment with acyclovir, and asymptomatic nephrotoxicity must be kept in mind.</.

• 出版日期2010-4