A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis

作者：Juo Suh Hang Hank; Wu Rita; Lin Chang Shen; Wu Ming Tsang; Lee Jau Nan; Tsai Eing Mei^*

来源：Fertility and Sterility, 2009, 92(4): 1228-1233.

DOI：10.1016/j.fertnstert.2008.08.015

• Interleukin-10
• polymorphism
• endometriosis
• inflammation

Objective: To investigate the involvement of inflammation in the development of endometriosis.
Design: Case-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, IL-1 beta, and cyclooxygenase-2.
Setting: University hospital.
Patient(s): We had 196 cases with pathologically proved endometriosis and 397 disease-free women as control subjects.
Intervention(s): A total of 12 single nucleotide polymorphisms (SNPs) were selected for genotyping, including functional SNPs and common tagging SNPs.
Main Outcome Measure(s): Logistic regression and haplotype analyses were performed to evaluate the genetic effect with adjustment for other covariates.
Result(S): Genotypes at each SNP were in Hardy-Weinberg equilibrium in either case or control subjects, except for rs1800871 at IL-10 in the case subjects (P=.04). We found that the individuals carrying minor allele C of a functional promoter SNP rs1800871 at IL-10 was associated with a reduced risk by approximately twofold compared with the common TT genotype. The T allele was reported to have a lower gene expression level than the C allele, suggesting inadequate suppression of inflammation leading to endometriosis development. Haplotype analysis of the IL-10 gene did not yield a better result. Other genes were not associated with endometriosis.
Conclusion(s): This study suggests that the functional promoter polymorphism at IL-40 may play a role in the development of endometriosis. (Fertil Steril (R) 2009;92:1228-33.

• 出版日期2009-10
• 单位河北医科大学