Aldo-keto reductase family 1 member B10 is associated with hepatitis B virus-related hepatocellular carcinoma risk

作者：Mori Masashi; Genda Takuya^*; Ichida Takafumi; Murata Ayato; Kamei Masato; Tsuzura Hironori; Sato Shunsuke; Narita Yutaka; Kanemitsu Yoshio; Ishikawa Sachiko; Kikuchi Tetsu; Shimada Yuji; Hirano Katsuharu; Iijima Katsuyori; Sugimoto Ken; Wada Ryo; Nagahara Akihito; Watanabe Sumio

来源：Hepatology Research, 2017, 47(3): E85-E93.

DOI：10.1111/hepr.12725

• AKR1B10 protein
• carcinoma
• chronic
• hepatitis b
• hepatocellular
• risk factors

AimRecent reports have indicated that aldo-keto reductase family 1 member B10 (AKR1B10), a cancer-related oxidoreductase, was upregulated in some chronic liver diseases. However, few studies have reported AKR1B10 expression in chronic hepatitis B virus (HBV)-infected patients. The aim of the present study was to analyze AKR1B10 expression and its relevance on hepatocellular carcinoma (HCC) development in patients with chronic HBV infection.
MethodsExpression of AKR1B10 in the liver of 119 chronic HBV-infected patients was assessed and quantified immunohistochemically. A multivariate Cox model was used to estimate the hazard ratios of AKR1B10 expression for HCC development. The cumulative incidences of HCC were evaluated using Kaplan-Meier analysis.
ResultsExpression of AKR1B10 in the study cohort ranged from 0% to 84%. During the median follow-up time (6.2years), 13 patients developed HCC. Multivariate analysis revealed that high AKR1B10 expression (15%) was an independent risk factor for HCC (hazard ratio, 10.8; 95% confidence interval, 3.0-38.6; P<0.001). The 5-year cumulative incidences of HCC were 20.6% and 2.6% in patients with high and low AKR1B10 expression, respectively (P<0.001). Patients with high AKR1B10 expression had significantly higher alanine aminotransferase levels during follow-up than those with low expression, even though antiviral treatment decreased HBV-DNA levels in both groups.
ConclusionChronic HBV-infected patients with high hepatic AKR1B10 expression had an increased risk of HCC development. This suggests that AKR1B10 upregulation might play a role in the early stages of HBV-related hepatocarcinogenesis.

• 出版日期2017-3