Magneto-fluorescent core-shell supernanoparticles

作者：Chen Ou; Riedemann Lars; Etoc Fred; Herrmann Hendrik; Coppey Mathieu; Barch Mariya; Farrar Christian T; Zhao Jing; Bruns Oliver T; Wei He; Guo Peng; Cui Jian; Jensen Russ; Chen Yue; Harris Daniel K; Cordero Jose M; Wang Zhongwu; Jasanoff Alan; Fukumura Dai; Reimer Rudolph; Dahan Maxime; Jain Rakesh K; Bawendi Moungi G^*

来源：Nature Communications, 2014, 5(1): 5093.

DOI：10.1038/ncomms6093

Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magnetofluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle 'core', which is fully surrounded by a 'shell' of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.

• 出版日期2014-10