Aliphatic polyester terpolymers for stent coating and drug elution: Effect of polymer composition on drug solubility and release

作者：Chan Seng Delphine; Ranganathan T; Zhang Xiongfei; Tang Yiwen; Lin Qing; Kleiner Lothar; Emrick Todd^*

来源：Drug Delivery, 2009, 16(6): 304-311.

DOI：10.1080/10717540902999653

• Polyester
• stent
• coating
• drug release
• everolimus

Ring-opening terpolymerization of L-lactide (LA), epsilon-caprolactone (CL), and glycolide (GA) was performed in the presence of tin (II) 2-ethylhexanoate at 170 degrees C. Random terpolyesters with weight-average molecular weight up to 130,000 g/mol were obtained. These terpolyesters, especially those with LA:CL:GA composition of 3:1:1, provided good coating integrity following spraying onto bare metal stents. The semi-synthetic macrolide immunosuppressant, everolimus, was incorporated into the terpolyester coating, and its release from the stent was evaluated. Unlike PLLA homopolymers, which are immiscible with the drug and non-optimal for controlled release, these terpolymers gave excellent control in a screening study, by tuning terpolymer molecular weight, relative monomer ratio, and drug-to-polymer ratio. Adjusting the polymer properties to improve drug solubility (or miscibility) in the polymer coating was found beneficial to the release profile.

• 出版日期2009-8