Nucleosome deposition and DNA methylation may participate in the recognition of premature termination codon in nonsense-mediated mRNA decay

作者：Niu, Deng-Ke^*; Cao, Jian-Li

来源：FEBS LETTERS, 2010, 584(16): 3509-3512.

DOI：10.1016/j.febslet.2010.07.046

• Nonsense-mediated mRNA decay
• Nucleosome deposition
• DNA methylation
• Premature termination codon

In non-mammalian eukaryotes, an abnormally long 30 untranslated region (UTR) is generally thought to be the definitive signal in the recognition of a premature termination codon (PTC) in nonsense-mediated mRNA decay (NMD). However, because the lengths of 30 UTRs in normal mRNAs are widely distributed, "abnormally long" is hard to define. Distinct peaks of nucleosome deposition and DNA methylation have recently been found at coding region boundaries. We propose that nucleosomes and DNA methylation just upstream of a normal stop codon are ideal indicators for the position of a normal stop codon and may thus serve as signals in PTC recognition.

• 出版日期2010-8-20
• 单位北京师范大学