Mannich- and Lederer-Manasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors

作者：Behery Fathy A; Sallam Asmaa A; El Sayed Khalid A^*

来源：Medchemcomm, 2012, 3(10): 1309-1315.

DOI：10.1039/c2md20185b

The Mannich-based analogues of S-(+)-curcuphenol (1), 3a-5a, and 3b potently inhibited the growth of several NCI's human cancer cell lines. In addition, 7a showed a 12-fold antimigratory activity (IC50 3.1 mu M) against the human breast cancer cell line MDA-MB-231 compared to its parent 1 (IC50 37.2 mu M).

• 出版日期2012-10