Phlorizin administration ameliorates cognitive deficits by reducing oxidative stress, tau hyper-phosphorylation, and neuroinflammation in a rat model of Alzheimer's disease

作者：Tian, Yuan; Lu, Weibing; Deng, Haohua; Yang, Fan; Guo, Yan; Gao, Ling; Xu, Yancheng^*

来源：Journal of Food Biochemistry, 2018, 42(6): e12644.

DOI：10.1111/jfbc.12644

• Alzheimer's disease
• neuro-inflammation
• oxidative stress
• phlorizin
• Tau

Phlorizin is a member of the chalcone class of organic compounds that was originally extracted from apples. Phlorizin also exhibits various bio-activities, such as anti-diabetes, anti-oxidation and anti-obesity. However, the effects of phlorizin on cognitive deficits or Alzheimer's disease (AD) are still unclear. Herein, we investigated its effects on A beta-induced cognitive deficits in a A beta-induced rat model of AD. Dietary treatment of 0.02% phlorizin for 10 weeks dramatically improved the learning and memory abilities during the Morris water maze test in AD rats. Mechanism studies suggested that phlorizin alleviated oxidative stress, tau hyper-phosphorylation, and neuro-inflammation in brain of rats. This research provides novel insight into the treatment effect of phlorizin on AD.

• 出版日期2018-12
• 单位华中科技大学; 湖北文理学院; 武汉市中心医院; 武汉大学; 青岛大学