Highly oxygenated chromones from mangrove-derived endophytic fungus Rhytidhysteron rufulum

作者：Chokpaiboon Supichar; Choodej Siwattra; Boonyuen Nattawut; Teerawatananond Thapong; Pudhom Khanitha^*

来源：Phytochemistry, 2016, 122: 172-177.

DOI：10.1016/j.phytochem.2015.12.010

• Rhytidhysteron rufulum
• Endophytic fungi
• Chromone
• Cytotoxicity

Five highly oxygenated chromones, rhytidchromones A-E, were isolated from the culture broth of a mangrove-derived endophytic fungus, Rhytidhysteron rufulum, isolated from Thai Bruguiera gymnorrhiza. Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The structure of rhytidchromone A was further confirmed by single-crystal X-ray diffraction analysis. These compounds were evaluated for cytotoxicity against four cancer cell lines (MCF-7, Hep-G2, Kato-3 and CaSki). All compounds, except for rhytidchromone D, displayed cytotoxicity against Kato-3 cell lines with IC50 values ranging from 16.0 to 23.3 mu M, while rhytidchromones A and C were active against MCF-7 cells with IC50 values of 193 and 17.7 mu M, respectively.

• 出版日期2016-2