A multicomponent, solvent-free, one-pot synthesis of benzoxanthenones catalyzed by HY zeolite: their anti-microbial and cell imaging studies

作者：Rama Velladurai; Kanagaraj Kuppusamy; Pitchumani Kasi^*

来源：Tetrahedron Letters, 2012, 53(9): 1018-1024.

DOI：10.1016/j.tetlet.2011.10.143

• HY zeolite
• Heterogeneous catalysts
• Benzoxanthenones
• Multicomponent reaction
• Solvent-free conditions

An atom-economical, multicomponent condensation of naphthols, aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by HY zeolites under solvent-free conditions is reported. This ecofriendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery, and reusability of metal-free solid acid heterogeneous catalyst and tolerance of a wide range of functional groups. The biological studies such as in vitro anti-microbial activities of the prepared new compounds and cell imaging studies on K562 leukemia cell lines by selected benzoxanthenones are evaluated.

• 出版日期2012-2-29