Development of the Asymmetric Hydrogenation of Enol Esters

作者：Wang, Zhihui; Zhang, Zhenfeng; Liu, Yan'gang; Zhang, Wanbin^*

来源：Chinese Journal of Organic Chemistry, 2016, 36(3): 447-459.

DOI：10.6023/cjoc201512009

• enol esters
• chiral alcohols
• asymmetric hydrogenation
• Ru-catalyzed
• Rh-catalyzed

Chiral alcohols are an important class of compounds and possess a broad array of applications, thus their asymmetric preparation is an important area of research in the field of organic synthesis. Amongst methodologies for the preparation of such compounds, catalytic asymmetric hydrogenation has gained widespread interest due to its efficiency, environmentally friendliness and economic advantages, and is gradually becoming a technology with great potential for the industrial preparation of chiral alcohols. This review provides the first overview for the catalytic asymmetric hydrogenation of enol esters for the synthesis of chiral alcohols. A comprehensive and up-to-date introduction are given for a number of different substrates. A thorough analysis is provided concerning the advantages and disadvantages of different chiral ligands and their transition-metal complexes. Finally, a brief discussion relating to developments and potential areas of further research concerning new substrates, new ligands and new catalytic metals, is presented.

• 出版日期2016-3
• 单位上海交通大学