ASYMMETRIC TOTAL SYNTHESIS OF STAGONOLIDE F

作者：Chinnababu B; Reddy S Purushotham; Babu K Suresh^*; Venkateswarlu Y

来源：Synthetic Communications, 2014, 44(19): 2886-2891.

DOI：10.1080/00397911.2014.905602

• Asymmetric dihydroxylation
• Jacobsen's hydrolytic kinetic resolution (HKR)
• ring-closing metathesis (RCM)

A highly convergent stereoselective total synthesis of stagonolide F is described starting from commercially available 5-hexen 1-ol using asymmetric dihydroxylation, Jacobsen's hydrolytic kinetic resolution (HKR), regioselective epoxide ring opening with vinyl Grignard reaction, esterification, and ring-closing metathesis (RCM) as key steps.

• 出版日期2014