"pH-triggered" drug release using shell cross-linked micelles from aqueous RAFT-synthesized PAPMA-b-NPNIPAM copolymers

作者：Yang, Zhenglong^*; Fu, Kangyu; Yu, Jing; Zhou, Peiting; Cheng, Zhihao

来源：Journal of Polymer Research, 2018, 25(8): 164.

DOI：10.1007/s10965-018-1564-9

• RAFT polymerization
• pH sensitive
• Shell cross-linked
• Micelles
• Controlled drug release

A new polymer namely poly (N-(3-aminopropyl) methacrylamide)-b-poly(N-isopropylacrylamide) (PAPMA-b-PNIPAM) was made for pH-triggered drug delivery by means of aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization. PAPMA-b-PNIPAM was hydrophilic at 25 degrees C, and micelles were formed at 39 degrees C. The PAPMA chain was crosslinked with terephthaldicarboxaldehyde at pH = 9.0 and shell cross-linking (SCL) micelles were prepared. The sizes of the SCL micelles were 45 similar to 65 nm which can be reversible dissociated under acidic conditions. The formation of temperature-responsive SCL micelles and their cleavage behaviours were characterized.

• 出版日期2018-7-4
• 单位同济大学