An efficient and simple synthesis of tetraketones catalyzed by Yb(OTf)(3)-SiO2 under solvent free conditions

作者：Rao V Kameshwara; Kumar Muthyala Manoj; Kumar Anil^*

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2011, 50(8): 1128-1135.

• Tetraketones
• ytterbium triflate
• three-component condensation
• Knoevenagel condensation
• Michael addition

A novel and efficient three-component one-pot condensation method has been described for the synthesis of tetraketones or arylmethylene[bis(3-hydroxy-2-cyclohexene-1-ones)] using Yb(OTf)(3)-SiO2 and amine as catalytic system under solvent free conditions. Tetraketones are obtained in high yield (73-88%). The application of an eco-friendly, non-corrosive, and reusable catalytic system makes this method advantageous.

• 出版日期2011-8