Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population

作者：Corrado Lucia; Bergamaschi Laura; Barizzone Nadia; Fasano Maria Edvige; Guerini Franca R; Salvetti Marco; Galimberti Daniela; Benedetti Maria Donata; Leone Maurizio; D'Alfonso Sandra^*

来源：Journal of Medical Genetics, 2011, 48(3): 210-211.

DOI：10.1136/jmg.2010.081380

Background The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia.
Objective To replicate this association in an independent population with a different genetic background.
Methods The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland.
Results It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 X 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52).
Conclusion These data provide further evidence of the association of MS disease with variation within CBLB.

• 出版日期2011-3