Atherosclerosis within the non-neoplastic margin of partial nephrectomy specimens: implications for medical management

作者：Gorin Michael A^*; Garcia Roig Michael; Garcia Buitrago Monica; Parra Herran Carlos; Jorda Merce; Ciancio Gaetano

来源：World Journal of Urology, 2013, 31(6): 1531-1534.

DOI：10.1007/s00345-012-0978-y

• Partial nephrectomy
• Pathologic evaluation
• Atherosclerosis
• Negative margin
• Statin

To describe the frequency and severity of atherosclerosis contained within the non-neoplastic tissue of partial nephrectomy (PN) specimens. %26lt;br%26gt;Archived open PN specimens were evaluated for histological evidence of atherosclerosis. Clinically significant atherosclerosis was defined as arterial luminal narrowing of %26gt; 25 % due to fibrointimal thickening. Histological findings were correlated with clinical data including history of major medical comorbidities and preoperative statin use. %26lt;br%26gt;The study cohort was comprised of 114 patients (71 men and 43 women). The mean age at the time of surgery was 59.3 years, and 69 (60.5 %) patients had a history of at least one major medical comorbidity including hypertension (54.5 %), diabetes (16.7 %) and coronary artery disease (12.3 %). Clinically significant atherosclerosis was observed in 29 (25.4 %) patients. These individuals were older (p = 0.001), and three times more likely to have greater than one major medical comorbidity (p = 0.002). In addition, only 17 (58.6 %) were prescribed a statin at the time of surgery. %26lt;br%26gt;Atherosclerosis is frequently observed in the non-neoplastic tissue of PN specimens. Patients found to have atherosclerosis can potentially benefit from intensive lifestyle modification and medical therapy with lipid-lowering medications. These measures would likely have the greatest clinical impact on those patients without an existing history of major medical comorbidities.

• 出版日期2013-12