A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized He-3 MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping

作者：Hamedani Hooman; Kadlecek Stephen; Xin Yi; Siddiqui Sarmad; Gatens Heather; Naji Joseph; Ishii Masaru; Cereda Maurizio; Rossman Milton; Rizi Rahim^*

来源：Magnetic Resonance in Medicine, 2017, 78(2): 611-624.

DOI：10.1002/mrm.26401

• hyperpolarized multibreath imaging
• hybrid (simultaneous) imaging
• alveolar oxygen tension
• specific ventilation
• oxygen uptake

PurposeTo present a method for simultaneous acquisition of alveolar oxygen tension (PAO2), specific ventilation (SV), and apparent diffusion coefficient (ADC) of hyperpolarized (HP) gas in the human lung, allowing reinterpretation of the PAO2 and SV maps to produce a map of oxygen uptake (R).
MethodAn imaging scheme was designed with a series of identical normoxic HP gas wash-in breaths to measure ADC, SV, PAO2, and R in less than 2min. Signal dynamics were fit to an iterative recursive model that regionally solved for these parameters. This measurement was successfully performed in 12 subjects classified in three healthy, smoker, and chronic obstructive pulmonary disease (COPD) cohorts.
ResultsThe overall whole lung ADC, SV, PAO2, and R in healthy, smoker, and COPD subjects was 0.200.03cm(2)/s, 0.39 +/- 0.06,113 +/- 2 Torr, and 1.55 +/- 0.35 Torr/s, respectively, in healthy subjects; 0.21 +/- 0.03cm(2)/s, 0.33 +/- 0.06, 115.9 +/- 4 Torr, and 0.97 +/- 0.2 Torr/s, respectively, in smokers; and 0.25 +/- 0.06cm(2)/s, 0.23 +/- 0.08, 114.8 +/- 6.0Torr, and 0.94 +/- 0.12 Torr/s, respectively, in subjects with COPD. Hetrogeneity of SV, PAO2, and R were indicators of both smoking-related changes and disease, and the severity of the disease correlated with the degree of this heterogeneity. Subjects with symptoms showed reduced oxygen uptake and specific ventilation.
ConclusionHigh-resolution, nearly coregistered and quantitative measures of lung function and structure were obtained with less than 1L of HP gas. This hybrid multibreath technique produced measures of lung function that revealed clear differences among the cohorts and subjects and were confirmed by correlations with global lung measurements. Magn Reson Med 78:611-624, 2017.

• 出版日期2017-8