Aryl-beta-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin

作者：Sakamaki Shigeki^*; Kawanishi Eiji; Nomura Sumihiro; Ishikawa Tsutomu

来源：Tetrahedron, 2012, 68(29): 5744-5753.

DOI：10.1016/j.tet.2012.05.035

Novel aryl-beta-C-glucosidation method using glucal boronate was developed. This protocol can offer several advantages including use of non-toxic, easily handling glucal boronate as a crystalline solid and storable at room temperature for several months. Tri-O-methylnorbergenin (8,10-di-O-methylbergenin), an anti-HIV active bergenin derivative, was concisely synthesized by application of the aryl-beta-C-glucosidation method.

• 出版日期2012-7-22