The TORC that Gets the GC Cycling

作者：Deenick Elissa K^*; Tangye Stuart G

来源：Immunity, 2017, 46(6): 974-976.

DOI：10.1016/j.immuni.2017.06.003

The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.

• 出版日期2017-6-20
• 单位河北医科大学