Direct access to the optically active VAChT inhibitor vesamicol and its analogues via the asymmetric aminolysis of meso-epoxides with secondary aliphatic amines

作者：Sharma Arun; Agarwal Jyoti; Peddinti Rama Krishna^*

来源：Organic and Biomolecular Chemistry, 2017, 15(8): 1913-1920.

DOI：10.1039/c6ob02479c

First highly enantioselective synthesis of biologically important vesamicol, benzovesamicol, and their derivatives was achieved via the desymmetrization of meso-epoxides with secondary aliphatic amines (4-phenylpiperidine derivatives) using a chiral [salenCo(III)-BF4] catalyst at room temperature. All products were obtained in good yield and with excellent optical induction.

• 出版日期2017