Short-Term Outcome and Hemodynamic Performance of Next-Generation Self-Expanding Versus BalloonExpandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus A Multicenter Propensity-Matched Comparison

作者：Mauri Victor; Kim Won K; Abumayyaleh Mohammad; Walther Thomas; Moellmann Helge; Schaefer Ulrich; Conradi Lenard; Hengstenberg Christian; Hilker Michael; Wahlers Thorsten; Baldus Stephan; Rudolph Volker; Madershahian Navid; Rudolph Tanja K

来源：Circulation: Cardiovascular Interventions , 2017, 10(10): e005013.

DOI：10.1161/CIRCINTERVENTIONS.117.005013

• follow-up studies
• heart valve prosthesis
• pacemaker, artificial
• propensity score
• transcatheter aortic valve replacement

Background-Surgical aortic valve replacement in patients with small annular dimensions is challenging because they are at increased risk for prosthesis-patient mismatch and impaired outcomes. Transcatheter aortic valve replacement might be a good alternative; however, comparative data on different transcatheter heart valves are missing.
Methods and Results-This multicenter, propensity score-matched study compared hemodynamics and early clinical outcomes in 246 patients with an aortic annulus area <400 mm(2) undergoing transcatheter aortic valve replacement with either a self-expanding transcatheter heart valve (Symetis ACURATE neo, n=129) or a balloon-expandable transcatheter heart valve (Edwards SAPIEN 3, n=117). The 1: 1 propensity score matching resulted in 92 matched pairs. For ACURATE neo versus SAPIEN 3-treated patients, 30-day mortality (0.0% versus 1.0%), 1-year mortality (8.3% versus 13.3%), incidence of stroke (3.3% versus 2.2%), life-threatening bleeding (1.1% versus 1.1%), and major vascular complications (2.2% versus 6.5%), as well as pacemaker implantation rate (12.0% versus 15.2%), were similar. Paravalvular regurgitation >= moderate was rare in both groups (4.5% versus 3.6%). The ACURATE neo presented lower mean transvalvular gradients (9.3 versus 14.5 mm Hg; P<0.001), larger indexed effective orifice areas (0.96 versus 0.80 cm(2)/m(2); P=0.003), and lower rates of severe prosthesis-patient mismatch (3% versus 22%; P=0.004). Hemodynamics were sustained at 1-year follow-up.
Conclusions-Albeit a similar safety profile with low clinical event rates, transcatheter aortic valve replacement with the ACURATE neo valve resulted in lower transvalvular gradients and consequently less prosthesis-patient mismatch compared with the SAPIEN 3 in patients with small annulus. These results emphasize the need of careful prosthesis selection in each individual patient.

• 出版日期2017-10