Diterpenoids from Isodon enanderianus

作者：Na Z; Xiang W; Niu XM; Mei SX; Lin ZW; Li CM; Sun HD^*

来源：Phytochemistry, 2002, 60(1): 55-60.

DOI：10.1016/S0031-9422(02)00073-0

• Isodon enanderianus
• labiatae
• ent-kaurane diterpenoids
• 6-epiangustifolin
• enanderinanin F-H

Four ent-kauranoids, 6-epiangustifolin and enanderinanins F H, as well as 11 known ent-kaurane diterpenoids, macrocalin B, xerophilusin A, trichorabdal A, trichorabdal B, effusin, angustifolin, longikaurin D, longikaurin F, enanderinanin B, xerophilusin G and shikokianin were isolated from the aerial parts of Isodon enanderianus. The new diterpenoids were identified as 6-epiangustifolin (11alpha-hydroxy-6alpha-methoxy-6,19-epoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide), enanderinanin F (19-acetoxy-6,20:6,11beta-diepoxy-6,7-seco-ent-kaur-16-en-15-one-1beta,7-olide), enanderinanin G (1beta,6beta,7beta-trihydroxy-19-acetoxy-16beta-methoxymethyl-7alpha,20-epoxy-ent-kaur-15-one) and enanderinanin H (6beta,7beta,14beta-trihydroxy-1alpha,11beta-acetonide-7alpha,20-epoxy-ent-kaur-16-en-15-one), respectively, on the basis of spectral data, especially by 2D NMR techniques. 6-Epiangustifolin showed significant cytotoxic activity against K562 cell.

• 出版日期2002-5
• 单位中国科学院昆明植物研究所