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摘要
This study aims to investigate the association of frailty with morning blood pressure and blood pressure variability in elderly patients with hypertension. 156 elderly patients with hypertension were divided into control group (non-frail group), pre-frail group and frail group according to the results of frail scale. Data on patients' gender, age, history of smoking, hypertension duration and anti-hypertensive drug usage were collected, their blood lipid, fasting blood glucose and blood uric acid were detected. The morning hypertension and variation of blood pressure were evaluated by monitoring the 24-hour ambulatory blood pressure in elderly patients with hypertension. Results showed that there were no significant differences in gender, age, history of smoking, hypertension duration, antihypertensive drug usage, Triglycerides, Total cholesterol, Low density lipoprotein cholesterol, High density lipoprotein cholesterol, Fasting glucose and Uric acid among the three groups (P>0.05). Morning SBP gradually decreased among control group, pre-frail group and frail group (P<0.01). However, no significant difference in morning DBP was observed among the three groups. 24 h SBP, daytime SBP, nighttime SBP, 24 h DBP, daytime DBP, night time DBP did not differ among the three groups (P>0.05). 24 h SBPV gradually increased among control group, pre-frail group, frail group (P<0.05). Daytime SBPV gradually increased among control group, pre-frail group, frail group (P<0.05). The nighttime SBPV, 24 h DBPV, daytime DBPV, nighttime DBPV did not differ among the three groups (P>0.05). The ordinal regression analyses showed that frailty was influenced negatively by morning SBP but had no effect on 24 h SBPV and Daytime SBPV. In conclusion, frailty is closely related to morning SBP, but not associated with blood pressure variability.
