Autoimmunity-associated autonomic failure with sympathetic denervation

作者：Goldstein David S^*; Holmes Courtney; Sullivan Patti; Donadio Vincenzo; Isonaka Risa; Zhong Elizabeth; Pourier Bobby; Vernino Steven; Kopin Irwin J; Sharabi Yehonatan

来源：Clinical Autonomic Research, 2017, 27(1): 57-62.

DOI：10.1007/s10286-016-0388-0

• Autonomic failure
• Sympathetic
• Catecholamine
• Norepinephrine
• Autoimmunity

We report a case of autoimmunity-associated autonomic failure in a young adult woman who developed arthritis followed 3 years later by pandysautonomia. There was early recovery of parasympathetic functions but persistent neurogenic orthostatic hypotension from post-ganglionic sympathetic denervation. Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years.

• 出版日期2017-2
• 单位NIH