A new asymmetric synthesis of the natural enantiomer of the indolizidino[8,7-b]indole alkaloid (+)-harmicine

作者：Allin Steven M^*; Gaskell Sean N; Elsegood Mark R J; Martin William P

来源：Tetrahedron Letters, 2007, 48(32): 5669-5671.

DOI：10.1016/j.tetlet.2007.06.034

We report a novel, facile and asymmetric approach for the synthesis of the indole alkaloid (+)-harmicine via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step, and verify the relative stereochemistry of the key synthetic intermediate in this approach through X-ray crystallography.

• 出版日期2007-8-6