Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation

作者：Guzman Ramos Kioko^*; Venkataraman Archana; Morin Jean Pascal; Osorio Gomez Daniel; Bermudez Rattoni Federico

来源：Behavioural Brain Research, 2018, 342: 89-93.

DOI：10.1016/j.bbr.2018.01.006

• Conditioned taste aversion
• Safe taste memory
• Insular cortex
• Amygdala
• Activity regulated cytoskeletal-associated protein

Several immediate early genes products are known to be involved in the facilitation of structural and functional modifications at distinct synapses activated through experience. The IEG-encoded protein Arc (activity regulated cytoskeletal-associated protein) has been widely implicated in long-term memory formation and stabilization. In this study, we sought to evaluate a possible role for de novo Arc protein synthesis in the insular cortex (IC) and in the amygdala (AMY) during long-term taste memory formation. We found that acute inhibition of Arc protein synthesis through the infusion of antisense oligonucleotides administered in the IC before a novel taste presentation, affected consolidation of a safe taste memory trace (ST) but spared consolidation of conditioned taste aversion (CTA). Conversely, blocking Arc synthesis within the AMY impaired CTA consolidation but had no effect on ST long-term memory formation. Our results suggest that Arc-dependent plasticity during taste learning is required within distinct structures of the medial temporal lobe, depending on the emotional valence of the memory trace.

• 出版日期2018-4-16