NMR relaxation dispersion of Miglyol molecules confined inside polymeric microcapsules

作者：Nechifor Ruben; Ardelean Ioan^*; Mattea Carlos; Stapf Siegfried; Bogdan Mircea

来源：Magnetic Resonance in Chemistry, 2011, 49(11): 730-733.

DOI：10.1002/mrc.2821

• NMR
• relaxation
• restricted diffusion
• polymeric capsules
• controlled drug delivery

Frequency dependent NMR relaxation studies have been carried out on Miglyol molecules confined inside core shell polymeric capsules to obtain a correlation between capsule dimension and the measurable parameters. The polymeric capsules were prepared using an interfacial polymerization technique for three different concentrations of Miglyol. It was shown that the variation of Miglyol concentration influences the capsule dimension. Their average size was estimated using the pulsed field gradient diffusometry technique. The relaxation dispersion curves were obtained at room temperature by a combined use of a fast field cycling instrument and a high-field instrument. The frequency dependence of relaxation rate shows a transition from a diffusion-limited to a surface-limited relaxation regime.

• 出版日期2011-11