The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study

作者：Kohli Indermeet; Shafi Rubina; Isedeh Prescilia; Griffith James L; Al Jamal Mohammed S; Silpa archa Narumol; Jackson Bradford; Athar Mohammed; Kollias Nikiforos; Elmets Craig A; Lim Henry W; Hamzavi Iltefat H^*

来源：Journal of the American Academy of Dermatology, 2017, 77(1): 33-+.

DOI：10.1016/j.jaad.2017.01.044

• colorimetry
• cyclobutane pyrimidine dimers
• excimer laser
• minimal erythema dose
• Polypodium leucotomos extract
• sunburn cells
• ultraviolet

Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).
Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.
Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.
Limitations: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.
Conclusion: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

• 出版日期2017-7