A limited sampling strategy for tacrolimus in liver transplant patients

作者：Zhu, Liqin; Wang, Hao; Rao, Wei; Qu, Wei; Sun, Liying^*

来源：International Journal of Clinical Pharmacology and Therapeutics, 2013, 51(6): 509-512.

DOI：10.5414/CP201876

• tacrolimus
• limited sampling strategy
• liver transplantation
• therapeutic drug monitoring

To develop limited sampling strategy (LSS) equations to estimate area under the curve (AUC(0-12)) in Chinese adult transplant patients. 26 adult liver transplant patients were included in this study. The blood samples, collected within 12 hours, were analyzed by microparticle enzyme immunoassay. By multiple stepwise linear regression analysis, LSS equations were identified. The predictive performance of these models was validated by the jackknife technique. As a result, the two sampling time point (trough and 4 hours postdose) model accurately predicted AUC(0-12). (R-2 = 0.949, ICC = 0.976). The two-point LSS equation (AUC(0-12)= 7.26 + (2.17C(0)) + (8.30 C-4)) can be used as a predictable measure of AUC(0-12) of tacrolimus in Chinese liver transplant patients.

• 出版日期2013-6
• 单位天津市第一中心医院; 天津医科大学