Drugs controlling proteinuria of patients with Alport syndrome

作者：Li, Jian-Guo; Ding, Jie^*; Wang, Fang; Zhang, Hong-Wen

来源：World Journal of Pediatrics, 2009, 5(4): 308-311.

DOI：10.1007/s12519-009-0059-5

• Alport syndrome
• angiotensin converting enzyme inhibitor
• herbal medicine
• tripterygium

Proteinuria is one of the risk factors for the progression of renal diseases including Alport syndrome (AS), a hereditary glomerular renal disease. This study aimed to evaluate the efficacy of angiotensin converting enzyme inhibitors (ACEIs) and/or tripterygium, a Chinese herbal medicine widely used in Chinese patients with hematuria and proteinuria, on proteinuria in patients with AS. @@@ Twenty-nine children were enrolled into this retrospective study. Patients were divided into 3 therapy groups: ACEI group, tripterygium group, and ACEI plus tripterygium group. @@@ In the 29 children, 23 were male and 6 female. In the ACEI group and the tripterygium group, the effective rate was 87.5% and 25.0%, respectively and in the ACEI plus tripterygium group was 42.9%. @@@ ACEI is effective in controlling proteinuria of AS patients. Tripterygium should be carefully administered in controlling proteinuria of AS patients.

• 出版日期2009-11
• 单位北京大学