A novel bioactive Cd(II) polymeric complex with mefenamic acid: Synthesis, crystal structure and biological evaluations

作者：Tabrizi Leila; Chiniforoshan Hossein^*; McArdle Patrick; Ebrahimi Malihe; Khayamian Taghi

来源：Inorganica Chimica Acta, 2015, 432: 176-184.

DOI：10.1016/j.ica.2015.04.010

• Cadmium(II)
• Mefenamic acid
• CT-DNA
• Cytotoxicity
• Antioxidant activity

A novel complex [Cd(mef)(2)(CH3OH)](n), 1, has been synthesized by the interaction of Cd(II) with the non-steroidal antiinflammatory drug mefenamic acid, mef, which has been structurally characterized by spectral (IR, UV-Vis) and X-ray crystallography. This complex is a 1D polymer, consisting of hepta-coordinated Cd atoms connected by six oxygen atoms from four different mef ligands and one oxygen atom from a methanol molecule. The coordination geometry around each metal ion is distorted by the bulky mef ligand. Binding of the synthesized complex with calf thymus DNA (CT-DNA) was investigated by spectroscopic methods (UV-Vis, fluorescence, CD spectroscopy) and viscosity measurements. The complex partially intercalated to DNA with high affinity. The antioxidant activities of ligand mef and complex 1 show this complex has better antioxidant activity than the free ligand. The antimicrobial activities of complex 1 are higher against both bacteria and fungi than free Cd2+ or mef. The cytotoxic effect of compound 1 on the human breast cancer cell line (MCF-7) and the bladder cancer cell line (T24) was also much higher than free Cd2+ or mef.

• 出版日期2015-6-1