Heritability and molecular genetic basis of electrodermal activity: A genome-wide association study

作者：Vaidyanathan Uma^*; Isen Joshua D; Malone Stephen M; Miller Michael B; McGue Matt; Iacono William G

来源：Psychophysiology, 2014, 51(12): 1259-1271.

DOI：10.1111/psyp.12346

• Skin conductance
• Electrodermal activity
• Habituation
• Heritability
• Genome-wide association study
• Molecular genetics

The molecular genetic basis of electrodermal activity (EDA) was analyzed using 527,829 single nucleotide polymorphisms (SNPs) in a large population-representative sample of twins and parents (N=4,424) in relation to various EDA indices. Biometric analyses suggested that approximately 50% or more of variance in all EDA indices was heritable. The combined effect of all SNPs together accounted for a significant amount of variance in each index, affirming their polygenic basis and heritability. However, none of the SNPs were genome-wide significant for any EDA index. Previously reported SNP associations with disorders such as substance dependence or schizophrenia, which have been linked to EDA abnormalities, were not significant; nor were associations between EDA and genes in specific neurotransmitter systems. These results suggest that EDA is influenced by multiple genes rather than by polymorphisms with large effects.

• 出版日期2014-12