Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium

作者：Kanamori Yuki; Iwasaki Arihiro; Sumimoto Shimpei; Matsubara Teruhiko; Sato Toshinori; Suenaga Kiyotake^*

来源：Journal of Natural Products, 2018, 81(7): 1673-1681.

DOI：10.1021/acs.jnatprod.8b00417

Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 mu M.

• 出版日期2018-7